Jodie Foster nurses criminals back to health in a 13 story-members-only-hotel, one night she helps out a crew after they robbed a bank and one of them gets shot. But due to other crimes and riots the same night, Foster already has a lot of patients to deal with and may have to break a few of her own rules.
As rioting rocks Los Angeles in the year 2028, disgruntled thieves make their way to Hotel Artemis -- a 13-story, members-only hospital for criminals. It's operated by the Nurse, a no-nonsense, high-tech healer who already has her hands full with a French assassin, an arms dealer and an injured cop. As the violence of the night continues, the Nurse must decide whether to break her own rules and confront what she's worked so hard to avoid.